Polynucleotides may be recommended for concerns such as fine lines, crepey or thinning skin, dullness, dehydration, reduced elasticity, acne scarring and delicate under-eye changes including dark circles and texture concerns. They can also be used on areas such as the neck, hands and décolletage where skin quality and firmness have started to decline.

Polynucleotides may be suitable if you are looking for a treatment that supports skin repair and rejuvenation without the look of added volume. They are often chosen by patients who want subtle, natural-looking improvement in skin tone, texture and elasticity, including in delicate areas such as under the eyes. A consultation is important to determine whether treatment is appropriate for your skin, medical history and goals.

Your appointment begins with a consultation to assess your concerns and plan the treatment carefully. The skin is cleansed, and the product is then placed into the superficial layers of the skin using a fine needle or cannula, depending on the area being treated and your practitioner’s approach. Treatment is usually quick, commonly taking around 60 to 90 minutes.

Most patients find polynucleotide treatment very tolerable. It is often described as a mild sting, pinch or tingling sensation during injection. Some clinics note that anaesthetic is not always required, although comfort can vary depending on the area treated and individual sensitivity.

After treatment, the skin may look slightly pink and feel a little puffy or tender for a short time. Small bumps at the injection sites, mild swelling or light bruising can occur, but these effects are usually temporary. Most patients are able to return to normal daily activities quite quickly.

Downtime is usually minimal. Mild redness, puffiness or bruising generally settles within a few days, and many patients feel comfortable resuming normal routines shortly afterwards. Your practitioner will advise you on aftercare, including sensible precautions such as protecting the skin from excess sun and following any guidance given for the treated area.

Polynucleotides work gradually, so results are not immediate. Early improvements are often noticed within a few weeks, with continued skin regeneration developing over the following 6 to 12 weeks. Treatment plans vary, but the sources commonly describe a course of around 2 to 4 sessions spaced a few weeks apart, followed by maintenance as needed. Longevity depends on your skin and treatment plan, though improvement is often reported for several months after a course.